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XZ: Formal analysis, Writing review & editing, Writing original draft

The key consideration is that Dihexa's effects persist beyond compound clearanceshifting protocols mid-study doesn't create an immediate reset but rather modulates ongoing neuroplastic processes already in motion

Although epithelium acts as a physical and antimicrobial barrier, ingested materials and enteric pathogens can promote inflammation by stimulating the production of proinflammatory cytokines, which further contribute to OS

(2021) Efficiency of the sublingual route in treating B12 deficiency in infants

Abbreviations CNS Central nervous system BDNF brain-derived neurotrophic factor CSF cerebrospinal fluid AD Alzheimers disease D H dopamine -hydroxylase A amyloid- APP amyloid precursor protein AA ascorbic acid AGEs advanced glycation end products RAGE receptors for AGE BBB blood brain barrier LRP-1 low-density lipoprotein receptor-1 GSH glutathione SSRIs selective serotonin reuptake inhibitors 4-HNE 4-hydroxynonenal MCI mild cognitive impairment ROS reactive oxygen species CDR Clinical Dementia Rating HPA hypothalamicpituitaryadrenal MMSE Mini-Mental State Examination CI confidence interval IQR inter-quartile range SMD standard mean deviation

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