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Of note, whereas drug adverse effects may emerge early because of the sudden exposure of the body to a new substance, adverse effects tend to be clearly present only when a critical threshold, usually related to blood level, is reached

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10.1016/j.canlet.2005.01.041 Cancer Lett

Hypomotility of facial muscles seems to be one of the determinant factors in early stages of the disease, as well as genetic polymorphism, in which lipid bioavailability is increased, both favoring an environment that favors Malassezia spp

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