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Too much protein, not enough carbs

Szretter KJ, Gangappa S, Lu X, Smith C, Shieh WJ, Zaki SR et al

While more human studies are necessary, researchers note in a 2016 review that the evidence for a protective role of DIM against breast cancer continues to grow. The review explains that DIM has demonstrated chemopreventive activity in all stages of breast cancer carcinogenesis.19 Some cell and animal studies on DIM for ovarian,20 gastrointestinal,21 and cervical cancer have shown promising results, as well.22 However, high-quality human trials are necessary before we can say anything definite about DIM for these cancers

Insulin-like growth factor binding protein-6 interacts with the thyroid hormone receptor 1 and modulates the thyroid hormone-response in osteoblastic differentiation

This metabolic shift reduces central serotonin availability while increasing neuroactive kynurenine metabolites, such as quinolinic acid, which enhance glutamatergic neurotransmission and promote excitotoxicity

von Bohlen und Halbach O, Dermietzel R