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Potentiation of Fas-mediated apoptosis by an engineered glycosylphosphatidylinositol-linked Fas

These results showed that H 2 O 2 -induced apoptosis was mainly through the mitochondrial pathway

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This work sheds light on why some patients continue to lose vision despite current treatmentsand where new treatments may emerge

46,47 These effects are mediated by SIRT1 pathway activation, which optimizes mitochondrial function and autophagy, and by miRNA-dependent regulation (e.g., miR-146a targeting Nrf2/NF-B pathways), although the mechanisms vary across cell types and microenvironments

Similarly, this marker can act as a potent antioxidant evidenced by marked alleviations of the NO and peroxynitrite levels, increasing total antioxidant capacity, and activating the SOD enzyme [166,167] also improving DAI, MPO activity and MDA content [168]