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Given that Trkb Penk -KO mice suffer from subtle deficits in their gait caused by reduced motor control 13 , we first scored mutants and controls at 34 months for supported and unsupported rearing

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Prolactin - a pleiotropic factor in health and disease

149 Under specific conditions, ROS can bypass these pathways to induce pyroptosis, driven by inflammasome activation (e.g., NLRP3) in response to PAMPs/DAMPs, the predominance of inflammatory caspases (caspase-1/4/5/11) over caspase-8 or RIPK3, and cell-specific mechanisms prioritizing cytokine release (IL-1/IL-18) in immune cells like macrophages

The modification of proteins may lead to conformational change and consequently activate transcription factors, which will in turn control the expression and accumulation of certain antioxidants, as described for E

Three tumors for each treatment condition were fixed in 4% paraformaldehyde (PFA) and paraffin-embedded in blocks for histology assessment