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Abell KM, Baker RS, Cowen DE, Porter JD

(2021) demonstrated that Lycopodium selago L

Regulatory T cell (Treg) development is also stimulated during hookworm infection ( Figure 1 Increasing Burden of Autoimmune Disease Autoimmunity is the failure of the immune system to distinguish pathogens from self-antigens resulting in damage to healthy tissue ( Dirty Old Friends The hygiene hypothesis, formulated in 1989, proposed that lower intensities of infections during early childhood could explain the emergence of asthma and hay fever later in life ( Concordantly, the old friends hypothesis suggests that various organisms, including helminths and microbiotas, have long coevolved with their mammalian hosts and act as inducers of immunoregulatory circuits ( Animal Models of Helminth Therapy Over the last decades, there have been numerous animal models used to study hookworm therapy for autoimmune disease (IBD, MS, RA, and T1D)

[PubMed] [Google Scholar] Abramov AY, Duchen MR

Acknowledgements This review was supported by the National Natural Science Foundation of China (82373039) and the University-Industry Collaboration Program (New Drug Targets and New Molecule Discovery and Technology 8210040001, 2020-019)

doi: 10.1186/ar551 9 PerlA