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As BioSpace reported, in February, Vinay Prasad, former director of the Center for Biologics Research and Evaluation, refused to file the application, but the agency's briefing documents published earlier this week suggest a more favorable view of the submission

Published data from cagrilintide research specifically demonstrates reductions in relative fat mass while maintaining relative lean mass

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In addition, mass spectrometry analysis with electrospray ionisation revealed that the intracellular concentration of ZIL was 10 4 10 3 % (w/v) after 2 h of cultivation in 5% (w/v) ZIL solution, while the intracellular DMSO concentration was reported to be approximately 1.6% (w/v) after 2 h of cultivation in 7.8% (w/v) DMSO solution 14 , indicating that ZIL is a non-cell-permeable reagent