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Rating: 4.4293000000000005 (27 reviews)

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*Correspondence: Yang Zhao [email protected] Zhu [email protected] This article was submitted to Parkinson's Disease and Aging-related Movement Disorders, a section of the journal Frontiers in Aging Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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At the molecular level, we explore key disruptions including proteostatic failure, aberrant phase separation, oxidative stress, neuroinflammation, synaptic dysfunction, iron dyshomeostasis, and impaired cholesterol metabolism

In a lateral hypothalamic-kindled rat model of acute mania, serum corticosterone levels increased with an altered dynamic in a mathematical model of the HPA axis [165]