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Aboul-Ella, H., Gohar, A., Ali, A

Nakahata, Y

and REDEFINE 11, a phase 3 trial with longer duration and patients with BMI 30 kg/m 2

Lipid accumulation is likely caused by increased lipid uptake and synthesis, decreased -oxidation and cholesterol efflux (25)

133 NAD + -dependent enzymes control redox homeostasis SIRT3 acts as an essential modulator of oxidative stress via deacetylation of substrates associated with both ROS generation and detoxification