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No new antibiotics have been produced in over 40 years, mainly because the big pharmaceutical companies have retreated from their antibiotic research programs due to the lack of incentives [143]

The expression of the syndecan family on the vascular endothelium includes SDC-1, SDC-2 and SDC-4 [29]

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Such strain-promoted cycloadditions offer intriguing and exciting possibilities for future protein labelling where the speed of labelling is vital, and recent developments suggest that the cyclooctyne-azide and cyclooctene-tetrazine reactions may have a degree of mutual compatibility, thereby allowing multi-site labelling 109,110