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In the PPMI cohort, amongst patients with sporadic PD (negative for GBA mutations), patients with higher CSF glucocerebrosidase-to-sphingomyelin ratios showed faster cognitive decline over 3 years, although the ratio did not show significant longitudinal changes 191

An optimal metabolism can cure excessive tiredness, excessive coldness, and other neurologic problems like dizziness and headaches

doi: 10.1038/sj.embor.7400933

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