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2.3.1 Negative regulatory factors of System Xc - Inhibiting cysteine uptake by System Xc - can inhibit the synthesis of GSH, leading to the accumulation of peroxides in the body and the induction of ferroptosis (64)

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doi: 10.1089/chi.2019.0040 Tulipano G (2021): Integrated or Independent Actions of Metformin in Target Tissues Underlying Its Current Use and New Possible Applications in the Endocrine and Metabolic Disorder Area

This conjugation facilitates their excretion from the body, making GSH a critical drug for treating liver failure, chemical poisoning, and adjunct therapy in chemotherapy to reduce neurotoxicity

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