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[,,] The liver is a unique anatomical and immunological site in which antigen-rich blood from the gastrointestinal tract is pressed through a network of sinusoids, which have small diameter and the fenestrations in the monolayer of sinusoidal ECs, all these may facilitate direct or indirect priming of lymphocytes, modulate the immune response to pathogens, and contribute to some of the unique immunological properties of the liver, particularly its capacity to induce antigen-specific tolerance

But the mainstream medical community had seen enough and largely moved on

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This reduces its potency and slows down its effects