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13 , e0191676

Tumor 71:241249 Marcelo Hermes-Lima, Kenneth B

Combined treatment reduced tumor burden in vivo , suggesting HMGB1-mediated ferroptosis sensitizes tumors to NK clearance ( 4 -treated cells, marked by reduced SLC7A11, GPX4, ferritin, and increased MDA, CD71, transferrin, and HMGB1

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In contrast to the well-characterized calcium-activated scramblase TMEM16F, XKR8 mediates lipid scrambling upon caspase-3-mediated cleavage at its carboxy-terminal recognition site during apoptosis, leading to the externalization of PS on the outer leaflet of plasma membrane (PM)

Expression of LOX family members were examined with publicly available database of NCBI-GEO, in the SMA+ HSCs of portal and periportal region of human liver biopsies with increasing METAVIR score, cultural activated freshly isolated qHSCs ex vivo , TGF1 activated human HSCs (LX2) in vitro during interaction with HCC, ECs and human monocyte THP1- derived polarized macrophage subsets