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Furthermore, a metabolic profiling study of 200 ME/CFS patients identified diminished serum amino acids essential for oxidative metabolism, alongside elevated expression of pyruvate dehydrogenase kinases (PDKs) in PBMCs, which inhibited pyruvate dehydrogenase (PDH)

Antonoff MB , Nguyen TC, Luc JGY, Fowler CS, Aultman Becker A, Eisenberg SB, Wolf RK, Estrera AL, Vaporciyan AA

J Am Soc Nephrol 2001

Tatsch E, De Carvalho J, Bollick YS, Duarte T, Duarte M, Vaucher RA, et al

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2.4 Oxidative damage biomarkers in the reproductive system Biochemical markers of oxidative damage provide important diagnostic and mechanistic insights into redox imbalance in reproductive biology (74)