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polygyrus infection can alleviate IBD by reducing the production of IFN- and IL-17 [146], inducing Foxp3 + Tregs, mucosal production of IL-10 [147,148], elevating Th2 cytokine expression, increasing mast cell infiltration [149] and by down-modulating Smad7 expression in intestinal CD4 + T cells [150]

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These two cytokines are involved in the upregulation of endothelial cell adhesion molecules, which likely affect the blood-brain barrier (BBB), which could exacerbate brain inflammation (Weiser et al., 2007)

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