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Acknowledgments We would like to thank the generous donors that have supported our work, especially Mona Eliassen and an anonymous family

Frame-shift mutations: If one or two nucleotides are either deleted from or added to the coding region of a mRNA, a frame-shift mutation occurs, altering the reading frame

For instance, while Hyaluronic Acid vs

An SD diet exacerbates weight loss, reduces colon length, and increases stool bleeding and diarrhea in models of DSS-induced colitis and in shPsat1 mice (short hairpin RNAs, shRNAs targeting the 2nd gene in the SSP pathway), consistent with worsened disease severity and inflammation 62,114

Several studies identified DNA-sensing pattern recognition receptors (PRRs) as drivers of IFN I-driven inflammation and massive cell death in severe COVID-19: cyclic GMPAMP synthase (cGAS), absent in melanoma (AIM)2, nucleotide-binding oligomerization domain (NOD)-like leucine-rich repeat (LRR) and PYRIN domain containing (NLRP)3, receptor for advanced glycation end products (RAGE), and Toll-like receptor (TLR)9 (9, 13, 14, 1723): Upon detecting double stranded (ds)DNA, these PRRs activate the production of antiviral and pro-inflammatory cytokines and chemokines and eventually, cell death, via two principal pathways (reviewed in (24, 25))

Short term storage at 2-8C is acceptable for up to 30 days without degradation