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Additionally, mRNA expression levels of RUNX-2 and ALP, two key osteogenic markers, were found to be 1.6- and 1.8-fold higher, respectively, in differentiated cells compared to undifferentiated controls

As crucial regulators of local immune responses and tissue repair, macrophages in diabetic wounds show dysregulated switching from M1 to M2, resulting in a poor regenerative environment, exacerbated tissue damage, and delayed wound healing 63

*This represents the average fold change of gene expression of the three GHK instances profiled in the cMap

About the product GHK-Cu (Glycyl-L-histidyl-L-lysine-Cu) is a naturally occurring copper peptide, delivered as an injection pen with a high concentration of 100 mg

The effects of GHK and GHK-PEG on malignant cell proliferation was first tested on U937 cells which were plated in 24 well plates and treated with GHK or PEGylated GHK at 10 and 20 nM for 24 hours and cell proliferation was assessed using a hemocytometer and the effect of each treatment was compared between control and treated samples using analysis of variance (ANOVA)

Under the supervision of Mr