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Neurotrophins perform their functions by binding to two different types of receptors, tyrosine kinase receptors and neurotrophic receptor 75

Ethics statement The animal study was reviewed and approved by Animal Ethical and Welfare Committee of Zhejiang Chinese Medical University

Cagrilintide can increase the sensitivity of leptin receptors and potentiate leptin-induced activation of signal transducer and activator of transcription 3 (STAT3), a transcription factor that mediates leptins effects on gene expression (Lutz et al., 2015, Front Endocrinol (Lausanne))

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