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D.WagnerB

Fife patients died 1, 3, 3 and 6 months after GC+D treatment initiation due to thrombosis (n=1) or cholangitis (n=4), all of which were ECOG 1 or 2 at treatment initiation

B.Balda NoriaG.GarcaA

ROS-producing enzymes involved in increased oxidative stress within vascular tissues include the NADPH oxidase (Nox), the xanthine oxidase and the mitochondrial respiratory chain

Macrophages are a type of immune cell

Mitochondria are the main organelles where iron utilization occurs in catabolic and anabolic pathways, and they serve an important role in iron metabolism, as well as material and energy metabolism (33)