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DCs promote T cell differentiation into Th1 cells by secreting IL-12, which plays a critical role in IFN- production (123, 124)

Several other investigators have also revealed that the activation of IGF-1R stimulated the p53-dependent cellular senescence, e.g., in human and mouse fibroblasts, human mesangial cells, and rat vascular smooth muscle cells [144,145,146]

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