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10.1038/s41390-019-0728-6 248 WilckenD

To explore the effects of the rec-ECM1 protein on liver fibrosis, we built a CCl 4 -induced liver fibrosis mice model based on the methodology outlined in a prior study [20], followed by treatment with two different doses (50 g/Kg or 150 g/Kg) of rec-ECM1 administered biweekly, along with the continuous administration of CCl 4 (Additional File 3 Fig

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The JAK inhibitor upadacitinib and the BTK inhibitor elsubrutinib are also tested in SLE patients in a phase 2 clinical study (ClinicalTrials.gov Identifier: NCT03978520)