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This led to significant interest in understanding the mechanisms and develop appropriate treatment strategies

-Sprava sa sklad: -Prav a av prah -Upevovacie prvky o rm -Sprava matc a skrutiek

For instance, FLT3-STAT3 signaling directly binds to the PD-L1 promoter and stimulates its transcription, while PRL2 indirectly upregulates PD-L1 through the TLR4-NF-B axis and suppresses the cytotoxic activity of T cells (84)