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In astrocytes, STAT3 signaling is induced by both pro- and anti-inflammatory molecules, including IFN- and cytokines of the IL-6 family, that bind to the gp130 cell-surface receptor to induce STAT3 phosphorylation (124127)

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This is especially important for biologics that can cross the blood-brain barrier to effectively control inflammatory injury and mitigate the corresponding deleterious effects on the brain and peripheral tissues