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314 A PEO mouse model with a C10orf2 defect has been established, 315 demonstrating that type IIB fibers of extraocular muscles are particularly vulnerable to mtDNA deletions, likely due to their relatively low mitochondrial content, which allows even a few mutant mtDNA to surpass the onset threshold

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In a study with type 2 diabetic rats, we verified our hypothesis by showing that adding salsalate to high fat diets enriched with 10% or 25% kcal of menhaden (fish) oil prevented the diabetes-induced decrease in motor and sensory nerve conduction velocity, intraepidermal nerve fiber density thermal nociception, cornea nerve density and sensitivity as well as vascular relaxation to acetylcholine and CGRP, to a greater extent than 10% or 25% menhaden oil alone (129)

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