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Hesperidin (HES) Hesperidin (HES) is a bioflavonoid with antioxidant effects that are widespread in citrus fruits [131, 132]

A decrease in the expression of transcription factors Nrf2 and PPAR, together with an increase in NF-kB expression, was observed in the renal cortex of L-NAME-induced hypertensive rats compared with control rats (0.3-, 0.8-, and 13-fold, respectively)

So while its promising, the benefits and risks must be weighed carefully

Plaques can become destabilized through rupture, erosion, or eruptive calcified nodules

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