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Increasing prefrontal BDNF experimentally reduced cocaine-seeking behavior, underscoring BDNF as a shared epigenetic target linking mood regulation and drug reward 42,176

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In the last decade, thorough reanalysis of these clinical observations provided the basis for well-defined criteria in future clinical trials

When analyzing patients' genetic backgrounds, environmental factors, and physiological statuses can benefit to personalize treatment plans, boosting therapeutic efficacy and prognosis management

Altered Neural Viability and Neurodegeneration Neuronal network morphogenesis is based on an effective equilibrium between neuroplasticity and neurodegeneration, as well as the formation of new cells through proliferation/survival signalling and cytoskeletal structures [120]

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