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Additionally, the microtubule-associated C4HC3-type E3 ligase, MEL, was found to promote SHMT1 degradation through the 26 S proteasome pathway, resulting in a reduction of endogenous SHMT1

10.1073/pnas.1322412111 Proc Natl Acad Sci U S A

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125 Surviving hepatocytes around areas of necrosis trigger KC apoptosis by increasing the expression of CXCR4 on redundant KCs following acute liver injury, which could influence liver regeneration

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