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Aragon CM, Rogan F, Amit Z

Importantly, in active intestinal inflammation, HIF-2 may exert context-dependent effects on ferroptosis susceptibility: even under systemic iron deficiency, local inflammatory cues can paradoxically enhance epithelial iron uptake and/or perturb subcellular iron distribution, thereby increasing the labile iron pool and promoting lipid peroxidation

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J Physiol Paris

To view a copy of this licence, visit About this article Cite this article Moir, N., Cauty, A., Rossignol, C

3.1.2.4 Macrophage The core mechanism of ferroptosis involves the dual effects of danger signal release and metabolic reprogramming, which regulate the remodeling of the macrophage inflammatory and polarized phenotype to reshape the tumor immune microenvironment