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The proposed mechanisms include upregulation of beta-3 adrenergic receptors in adipose tissue, activation of the cAMP-PKA lipolytic cascade through enhanced catecholamine sensitivity, direct or indirect inhibition of acetyl-CoA carboxylase (ACC) reducing de novo lipogenesis by approximately 43-57% in vitro, and activation of hormone-sensitive lipase (HSL) with increased glycerol release

Imiquimod, similar to tremelimumab (anti-CTLA-4 antibody IgG2 isotype), may replenish effector and memory TILs without influencing the proportion of Tregs (37)