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Amino acid restriction and ER stress are two major stresses which activate the ISR and both pathways converge on eIF2 14

62 Despite these indications of tumor sensitivity to insulin, it is not clear to which extent the modulation of insulin and IGF-1 levels is able to influence the proliferation of progressive cancers that have become self-sufficient in growth and metabolic signals as illustrated for example by: (i) expression of insulin-independent glucose transporter isoforms

Buschauer, R

Understanding its properties provides the baseline for comparing all other variants

Fibroblast growth factor 23 predicts incident diabetic kidney disease: a 4.6-year prospective study