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Among experts, a clinically meaningful change in ALSFRS-R in clinical trials would be a reduction of about 20% in the slope of rate of decline [34]

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Supports energy production, fat metabolism, and endurance

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8 Vitamin B12 can help to regulate the synthesis of neurotransmitters, particularly serotonin, which may be low after taking an SSRI

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PMID: 16785472

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For those over 65, he suggests DHEA hormonal support and antioxidant defense to protect against oxidative damage, recommending quercetin as a specific antioxidant for fatty tissue protection

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