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Muzii L, Di Tucci C, Galati G, Carbone F, Palaia I, Bogani G, et al

doi: 10.1530/rep-09-0092 263 LeguyMCBrunSPidouxGSalhiHChoisetAMenetMCet al

The mechanisms responsible for inner HC synapse loss have not been determined with certainty, but glutamate toxicity is a strong candidate

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Other measures to target hypoxia include targeting hypoxia-induced signaling pathway proteins (such as HIF-PHD-pVHL pathway proteins and mTOR pathway proteins, etc.) and increasing oxygen supply through vascular normalization (such as the use of antiangiogenic drugs, etc.) (198200) ( Figure 3 )