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DISCUSSION In this study, we successfully applied CRISPR/Cas9 technology to generate a stable genetic ndufs2 -/- 16 bp deletion zebrafish line that had 80% reduced CI enzyme activity, 96% reduced ndufs2 mRNA expression, significantly reduced lifespan (mean 10 dpf, max 11 dpf), swimming-based neuromuscular activity, and multiple gross morphological changes including linear growth defect, hepatomegaly, uninflated swim bladder, yolk retention, small intestinal size, and small eye and pupil size with an abnormal retinal ganglion cell layer

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Even if youre healthy in every other way, drinking on a daily basis can make lung glutathione levels plummet by 90% or more

In conclusion, both the ethyl acetate fraction extract of pigeonweed and the aqueous extract of musk can play a role in the protection of the central nervous system by regulating the key pathways of ferroptosis and related biomarkers

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These molecules aid clearance of the damaged tissue but can also induce harm to healthy surrounding tissue ( As shown, muscle injury evoked by exercise is a complex response including multiple cells and multiple molecules (Figure 1)