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Plenker, D

In addition to its role in energy production via the TCA cycle, -KG plays a central role in amino acid synthesis, redox balance, and the regulation of cell signaling

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Gastrointestinal issues

After treatment with the NOS inhibitor, N G -monomethyl-L-arginine, a threefold greater decrease of blood flow was detected in anemic patients compared with healthy controls and it was proposed that under anemic conditions, NO bioavailability may be increased by a decreased Hb-dependent inhibition of NO inactivation

Pregnant or nursing mothers should avoid it, as there isn't enough research to confirm its safety