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SIRT2, present both in nuclear and cytoplasmic compartments, can increase MFN2 and decrease DRP1, thus promoting mitochondrial fusion 104,105

Mimicking the Effects of Exercise Since MOTS-c activates many of the same downstream pathways triggered by physical activity, including AMPK signaling, increasing mitochondrial efficiency, and improving fatty acid oxidation, MOTS-c has also been called an exercise mimetic in scientific literature

G., Quadir, M

Treated wounds also show increased collagen deposition and enhanced angiogenesis, with new blood vessel formation supporting healing tissue with improved nutrient delivery