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Plasmid constructs and cell procedures Plasmid constructs expressing human WT SOD1 (SOD1 WT ) and human SOD1 with G93A mutation (SOD1 G93A ) originally generated by the Fisher lab were obtained through Addgene 20

Neuroprotection: It helps protect brain tissue from oxidative stress, which is linked to neurodegenerative conditions

Ahmed MM, Ibrahim ZS, Alkafafy M, El-Shazly SA

doi: 10.1111/ejn.15676 157

Finally, there are two isoforms of SHMT in mammals, one cytoplasmic and the other mitochondrial 45,59,66 , and the same might be true for worms

The impact of changed redoxin function on ferroptosis could also be based on secondary effects, e.g., the increase in superoxide formation upon loss of mitochondrial redoxins [90,91] or activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway [92,93] , a major regulator of transcription of antioxidant and anti-ferroptotic enzymes [65]