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Description

Targeted inhibition of glutaminolysis with the Gls1 inhibitor CB-839 and BPTES, and genetic silencing by Gls1 short interfering (si)RNA, only reduced the expression of collagens, but not that of FN or -SMA

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10.1021/acsami.0c00355

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Convenient and time saving

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it regulates histone acetylation by suppressing histone acetyltransferases and histone deacetylases, thereby restoring normal chromatin accessibility

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These elevated amino acids activate the mTOR-STAT3 and ERK-CREB pathways, increasing both VGF and glucagon transcription in cells

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[DOI] [PMC free article] [PubMed] [Google Scholar] 129.Vicente-Salar N., Fuster-Muoz E., Martnez-Rodrguez A

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