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ROS in ECs are mainly derived from mitochondria, NADPH oxidase (NOX), endothelial NOS (eNOS) uncoupling, and xanthine oxidase (XO) ( Figure 2 )

These ROS further stimulate A production by activating - and -secretases, creating a deleterious feed-forward loop that accelerates neuronal loss (79)

Application of Exosomes Providing a Novel View for Ferroptosis-Based Cancer Treatment Modified exosomes can be selectively used to deliver drugs to specific cells and present advantages, such as high effectiveness and reduced toxicity