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In contrast, loss of glutaredoxins does not affect glutathione concentration or redox state

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Protective effects of shikonin on brain injury induced by carbon ion beam irradiation in mice

In one melanoma study, mice exposed to higher NAC doses experienced greater metastatic activity than those given lower doses, suggesting the effect may be dose-dependent in certain experimental settings.42 Researchers have not established whether these findings apply to humans, but starting with a moderate dose offers a more conservative approach while still aligning with a large portion of the clinical literature

Ecotoxicol Environ Saf 277: 116343