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These metabolites influence the survival and function of neighboring cells within the same environment, thereby establishing bidirectional metabolic communication between T cells and their surroundings

Moreover, advances in computational biology and AI-based prediction tools now facilitate more systematic identification of repurposing compounds, thereby reducing reliance on serendipity (Xu Y

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Schmitz et al, 2018), we specifically focused on NF-B family members

Physiologic GH exposure, whether endogenous or therapeutically restored, has not demonstrated a measurable increase in cancer risk