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In contrast, resveratrol alleviates PAEC dysfunction in CTEPH rats by enhancing autophagy [96]

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By superoxide dismutase (SOD), the superoxide (O 2 - ) can be transformed into hydrogen peroxide (H 2 O 2 ), which can be further transformed to a number of other ROS such as hydroxyl radicals (OH) and hydroxyl anions (OH - )

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This ability to recognize a chemically diverse array of endogenous ligands, including amino acids, organic acids, and secondary metabolites, underscores the phytochemical adaptability of plant GLRs and their evolutionary divergence toward metabolic signalling

We particularly focus on deliberate structural and chemical modifications that are made directly to the protein structure as opposed to strategies such as directed evolution and protein encapsulation, or those focusing on tuning protein formulations