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Glutathione prevents the activation of Tyrosinase by reducing free radicals in the body that can activate it and cause an increase in melanin production

Additionally, a mechanistic investigation has revealed that siRNA administration to cancer cells activated innate immune response and reduced the expression of indoleamine 2,3-dioxygenase 1 (IDO1), an enzyme responsible for immunosuppression

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Goodman and Gillman's The Pharmacological Basis of Therapeutics, 9th ed