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meningitidis adheres to CNS capillaries and actively crosses BBB by disrupting cellcell junction in subarachnoid space [28]

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Taken together, this could explain why a mutation in MTND5 subunits at lower mutant load could result in severe cases of LS and other complex I related disorders such as MELAS (mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes) or LHON (Lebers hereditary optic neuropathy)

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Affinity chromatography matures as bioinformatic and combinatorial tools develop