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Other studies have described reduced tumor growth and angiogenesis-related markers in experimental systems, potentially through modulation of Akt- and NF-B-associated signaling responses [82]

Knockdown of SPI1 combined with erastin promotes ferroptosis in a ccRCC xenograft mouse model The effect of SPI1 on ferroptosis in ccRCC development was further demonstrated in vivo based on a xenograft mouse model

Binding activity of the R573D mutant of ASXL1 EBM was substantially decreased (Fig

Mukai T, Kishi T, Matsuda Y, Iwata N

For example, icariin (ICA) can upregulate GPX4 expression, reducing MDA levels and iron content in synovial cells, thereby activating the System Xc /GPX4 axis to inhibit ferroptosis and alleviate synovial inflammation (Wang et al., 2016

The decline in BAT activity with age further compromises metabolic homeostasis (406), although some fat redistribution patterns may serve protective functions in extreme old age (413)