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doi: 10.1016/j.pharmthera.2023.108357

2019 Jun Advait Vasavada, Preeti Patel, Devang K

Many find these approaches difficult to adhere to, with physical and emotional burnout becoming common roadblocks

These include: Nausea (most common, especially during dose escalation) Vomiting Diarrhea Constipation Reduced appetite (expected and part of the mechanism) Abdominal discomfort These effects are most pronounced during dose titration and tend to diminish over time as the body adapts

For the fuller story on the peptide boom and what the evidence actually says, see my Economist feature: Want to hack your body with peptides