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Proc Natl Acad Sci U S A[Internet]

8-OHdG Context: Reflects total body oxidative stress, not estrogen-specific, but reinforces metabolic-genotoxic overlap when paired with estrogen metabolite imbalances.

It addresses functional B-vitamin insufficiency, particularly during periods of stress or increased metabolic demand, while avoiding imbalance that can occur when single B vitamins are given in isolation

Therefore, further research is warranted to investigate the therapeutic potential of SCFAs supplementation via microbiota modulation in combination with targeted therapies