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Ferroptotic tubular cells release DAMPs (e.g., HMGB1) and lipid peroxidation products (e.g., 4-HNE), which activate pattern recognition receptors on macrophages and neutrophils, inducing the secretion of pro-inflammatory cytokines (e.g., IL-33 and MCP-1)

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Arterioscler Thromb Vasc Biol 16 : 878882

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In a retrospective cohort study by Korlipara et al., after accounting for confounding factors, semaglutide use was associated with a 6% increase of retained solid gastric contents [47]