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Psoriasin was first identified as a secreted protein in extracts of human skin from psoriasis patients [93]

acnes produces porphyrins, an inflammatory compound that produces acne

Indeed, the SCCNVs could be produced by inducing senescence ex vivo in the cancer cells of patients and after several steps of purification, SCCNVs could be re-injected into the patients

KIM-1 has a numerous features of ideal biomarker such as absence in normal kidneys and increasing expression after renal injury, significant relationship between urine and tissue level of KIM-1 and correlation with the severity of renal dysfunction 51

Cartilage faces even greater obstacles given avascular nature (no blood vessels penetrating tissue), low cell density (chondrocytes sparse within extensive extracellular matrix), minimal metabolic activity (slow turnover and repair), and mechanical loading challenges (constant stress impeding healing)