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Notably, the upregulation of one-carbon metabolism is more robust in TP53 mut AML and only the TP53 mut AML clones increase levels of the polyamines, spermidine and spermine, in response to AraC

igf-1 lr3 ZPHC (5 x 0.2 ) , , - BigZi , 5215747132 IGF-1LR3 | 1mg

Dennis Hurwitz

doi: 10.1016/j.freeradbiomed.2018.05.001 230 JiangCWangZGantherHLJ

doi:10.1016/j.jconrel.2022.12.001

A similar inverse relationship between fluid and brain protein levels is seen with amyloid beta, whereby lower CSF AB42 is correlated with increased AB plaques in the brain 40